Publications

SCORE Publications from all partners during the first six months of the project period.

All publications have been pre-published on the bioRxive sever.

 

  • The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2   Natacha S. Ogando, Jessika C. Zevenhoven-Dobbe, Yvonne van der Meer, Peter J. Bredenbeek, Clara C. Posthuma, Eric J. Snijder.  J. Virol. 2020  doi: 10.1128/JVI.01246-20 / https://jvi.asm.org/content/jvi/early/2020/09/10/JVI.01246-20.full.pdf

 

  • A molecular pore spans the double membrane of the coronavirus replication organelle  Georg Wolff, Ronald W.A.L. Limpens, Jessika C. Zevenhoven-Dobbe, Ulrike Laugks,bShawn Zheng,, Anja W. M. de Jong, Roman I. Koning, David A. Agard, KayGrünewald, Abraham J. Koster, Eric J. Snijder, Montserrat Bárcena Science 2020 doi: https://doi.org/10.1101/2020.06.25.171686

 

  • Drugs against SARS-CoV-2: What do we know about their mode of action? Coralie Valle , Baptiste Martin , Franck Touret , Ashleigh Shannon , Bruno Canard , Jean-Claude Guillemot , Bruno Coutard , Etienne Decroly. Rev Med Virol. 2020 Aug 11 : e2143  doi: 10.1002/rmv.2143

 

  • Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Zhang L., Lin D., Sun X., Curth U., Drosten C., Sauerhering L., Becker S., Rox K., Hilgenfeld R. (2020): Science. 368, 409-412. doi: 10.1126/science.abb3405

 

  • Substrate specificity profiling of SARS-CoV-2 main protease enables design of activity-based probes for patient-sample imaging. Rut W.#, Groborz K.#, Zhang L.#, Sun X.,  Zmudzinskia M., Pawlik B., Wang X., Jochmans D., Neyts J., Młynarski W., Hilgenfeld R., Drag M. Nat. Chem. Biol 2020 doi:https://doi.org/10.1101/2020.03.07.981928

 

  • Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Thi Nhu Thao T, Labroussaa F, Ebert N, V'kovski P, Stalder H, Portmann J, Kelly J, Steiner S, Holwerda M, Kratzel A, Gultom M, Schmied K, Laloli L, Hüsser L, Wider M, Pfaender S, Hirt D, Cippà V, Crespo-Pomar S, Schröder S, Muth D, Niemeyer D, Corman VM, Müller MA, Drosten C, Dijkman R, Jores J, Thiel V. Nature. 2020 Jun;582(7813):561-565. doi: 10.1038/s41586-020-2294-9

 

  • SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology. Ogando NS, Dalebout TJ, Zevenhoven-Dobbe JC, Limpens RWAL, van der Meer Y, Caly L, Druce J, de Vries JJC, Kikkert M, Bárcena M, Sidorov I, Snijder EJ. J Gen Virol. 2020 Jun 22. doi: 10.1099/jgv.0.001453

  

  • A molecular pore spans the double membrane of the coronavirus replication organelle. Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M. Science. 2020 Sep 11;369(6509):1395-1398. doi: 10.1126/science.abd3629.

 

 

  • A Fluorescence-based High Throughput-Screening assay for the SARS-CoV RNA synthesis complex.Cecilia Eydoux, Veronique Fattorini, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Bruno Didier, Bruno Canard, Jean-Claude Guillemot bioRxiv 2020.07.07.192005; doi:  10.1101/2020.07.07.192005

 

  • A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate. Lorena Sanchez Felipe, Thomas Vercruysse, Sapna Sharma, Ji Ma1, Viktor Lemmens Dominique van Looveren, Mahadesh Prasad Arkalagud Javarappa, Robbert Boudewijns, Bert alengier-Devlies, Suzanne F. Kaptein, Laurens Liesenborghs, Carolien De Keyzer, Lindsey Bervoets, Madina Rasulova, Laura Seldeslachts, Sander Jansen, Michael Bright Yakass, Osbourne Quaye, Li-Hsin Li, Xin Zhang, Sebastiaan ter Horst, Niraj Mishra, Lotte Coelmont, Christopher Cawthorne, Koen Van Laere, Ghislain Opdenakker, Greetje Van de Veld, Birgit Weynand, Dirk E. Teuwen, Patrick Matthys,  Johan Neyts https://doi.org/10.1101/2020.07.08.193045doi
  • Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis.  Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, François Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen & Bruno Canard. Nat Commun. 2020 Sep 17;11(1):4682. doi : https://doi.org/10.1038/s41467-020-18463-z